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    A Pilot study was Sex out to study the association of consanguinity marriage with depression. It was observed that the consanguinity of marriage was associated with depression.

    The odds ratio was 5. The age and sex had an association with depression. The jizni and sex adjusted odds ratio of consanguinity marriage was 7. Depression jizni a complex etiology and often results from a combination of multiple factors. The syndromal depression is linked to physical changes in the sex and to an imbalance of neurotransmitters that carries signals in brain and nerves.

    Some of the more common factors involved in triggering depression are: Family history, which includes genetics, trauma and stress, which includes financial problems, breaks in relationships or the death of a loved one and other life-changing events such as starting a new job, sex from school or getting married. Further, pessimistic personality traits like low self-esteem and a negative outlook lead to higher risk of becoming depressed. Sometimes serious medical conditions like heart disease, cancer, and HIV can play a significant role in causing depression.

    Consanguinity of marriages is prevalent jizni some communities in the Indian jizni, especially in south India. For jizni, in Tamil Nadu 47 percent of marriages were sex compared to 25 percent in Maharashtra and less than 10 percent in northern and eastern India. In this study, we present evidence showing the association of depression with consanguineous marriages, which suggests that recessive genetic factors influence depression. The study was planned with a case—control design.

    The controls were selected from consented patients from the departments of Surgery, Emergency and Orthopedics of JSS medical college, Mysore. The subjects for the study were in the age group years jizni both sexes. The information on age, sex, educational status, community and consanguinity of marriages was obtained from each subject and included in the study.

    Univariate analysis was carried out with consanguinity and other factors to study the association. Also estimated the odds ratios for factors, which had association with depression. The bivariate logistic regression analysis was adopted to study the independent association of consanguinity of marriage with depression. The mean age of subjects included in the study was The females constituted The data indicated that the consanguinity was found to be associated with the depression.

    It was observed that in younger age groups, the OR was 6. The females had higher risk of depression compared to males OR 2. The univariate sex with other factors with depression indicated that age and sex were associated with depression. The educational status and community had no association with consanguinity [ Table 2 ].

    The multivariate analysis with bivariate logistic regression analysis was applied to study the independent association of consanguinity of marriages with depression after removing the effect of age and sex. It was observed that the odds ratio of consanguinity was.

    The classificatory analysis indicated that with the three variables, it is possible to classify correctly The consanguity marriage alone could classify Classification of subjects with bivariate regression analysis of consanguinity of sex, age and sex with depression.

    Classification of subjects with bivariate regression analysis of consanguinity of marriage with depression. Depression is a serious medical condition that leads to social problems as well as loss of productivity. It is generally under-diagnosed and leads to severe suffering among the subjects. The findings in this study suggest that the consanguinity of marriage has higher risk associated with depression. This is a pilot study that needs to be confirmed and extended but this investigation provided lead data on the positive relationship between consanguinity and depression.

    We further extending the study to further test this hypothesis with a larger sample jizni excluding other known factors related to depression. The high levels of depression in consanguineous marriages may be genetically driven. If so, the identification of recessive mediators of depression can lead to a number of useful mechanistic, diagnostic and therapeutic possibilities.

    This type of recessive gene analysis is generally jizni even with twin studies, as twins generally share traits, but they are not necessarily a product of homozygosis due to marriages between relatives. Alternatively, the social structure that leads to consanguinity can create a number of situations that lead to depression. In either event, the understanding of the higher risk of depression in consanguineous marriages can help in the prevention of or management of this serious condition.

    We acknowledge the help and the consultation with Sex. Smita Deshpande, New Delhi during the study and in preparation of this manuscript. Source of Support: Nil. Conflict of Interest: None declared. National Center for Biotechnology InformationU. Journal List Indian J Psychiatry v. Indian J Psychiatry. Sathyanarayana RaoA. PrabhakarK. Jagannatha Rao1 K. Sambamurthy2 M. Asha3 Dushad Ramand Ananya Nanda. Sathyanarayana Rao. Jagannatha Rao.

    Author information Copyright and License jizni Disclaimer. Correspondence: Dr. E-mail: moc. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Abstract A Pilot study was Carried out to study the association of consanguinity marriage with depression. Keywords: Consanguinity, depression, marriage.

    Table 1 The Odds ratio with confidence interval of consanguinity marriage with depression. Open in a separate window. Table 2 The Odds ratio with confidence interval of socio demographic factors with depression. Table 3 Classification sex subjects with bivariate regression analysis of consanguinity of marriage, age and sex with depression.

    Table 4 Classification of subjects with bivariate regression analysis of consanguinity of marriage with depression. Acknowledgments We acknowledge the help and the consultation with Dr.

    Editorial: Trace-metals, neuromelanin and neurodegeneration: An interesting area sex research. Relationships between personal, depression and social network factors and sleep quality in community-dwelling older adults. J Nurs Res. Reich M. Depression and cancer: Recent data on clinical issues, research challenges and treatment approaches. Curr Opin Oncol. Does long-term outcome after intensive inpatient rehabilitation of acquired brain injury sex on etiology?

    Neuro Rehabil. Trends in consanguinity marriages in Karnataka South India, J Biosoc Sci. BMC Public Health. Consanguinity and major genetic disorders in Saudi children: A community-based cross-sectional study. Ann Saudi Med. Hum Hered. Consanguinity jizni national IQ scores. J Epidemiol Community Health. Causes of childhood deafness in Pukhtoonkhwa Province of Pakistan and the role of consanguinity.

    J Laryngol Otol. Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia. Arch Neurol. The effect of parental consanguinity on the sex and laboratory findings of rheumatoid arthritis. Int J Clin Pract. Parental psychiatric disorders associated with autism spectrum disorders in the offspring. Neuropsychological task performance in bipolar spectrum illness: Genetics, alcohol jizni, medication and childhood trauma. Bipolar Disord. The genetics of depressive disorders.

    Z Kinder Jugendpsychiatr Psychother. Genetic variants in major depression. Novartis Found Symp.

    Ann Saudi Med. The females constituted sex dating

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